Nicotine administration and withdrawal affect survival in systemic inflammation models

Nicotine administration and withdrawal affect survival in systemic inflammation models.

How different regimens of nicotine administration and withdrawal affect systemic inflammation is largely unknown. We studied the effects of chronic and acute nicotine administration and of nicotine withdrawal on the outcome of aseptic and septic systemic inflammation. Male C57BL/6 mice were implanted with subcutaneous osmotic pumps (to deliver nicotine) and intrabrain telemetry probes (to measu...

TRANSLATIONAL PHYSIOLOGY Nicotine administration and withdrawal affect survival in systemic inflammation models

Steiner AA, Oliveira DL, Roberts JL, Petersen SR, Romanovsky AA. Nicotine administration and withdrawal affect survival in systemic inflammation models. J Appl Physiol 105: 1028–1034, 2008. First published July 10, 2008; doi:10.1152/japplphysiol.90619.2008.—How different regimens of nicotine administration and withdrawal affect systemic inflammation is largely unknown. We studied the effects of...

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.

Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after ab...

Nicotine withdrawal in women.

Associations between self-report symptom profiles for nicotine withdrawal, personality (TPQ, EPQ-R), life-time history of psychopathology and smoking history were examined in data obtained from 553 female adult Australian twins (246 regular smokers), aged 32-48 years, who had participated in a telephone interview survey that included life-time assessments of smoking history, nicotine dependence...

[Nicotine withdrawal symptoms in newborns].